As a basic scientist by training, my research has initially included both pre-clinical and human interventions, but since the last ~20 years I have focused my research on human translational intervention studies. Currently I work at the German Diabetes Center in Düsseldorf, Germany. At CHE I aim to contribute to the further stimulation of the translational relevance of the excellent metabolic investigations, and provide my expertise and ongoing research on collaborative projects. In particular, I will collaborate on topics including mitochondrial function in muscle, adipose tissue and liver, the effects of prolonged fasting on (human) metabolism, exercise and nutritional effects on inflammation and energy metabolism, brown adipose tissue as well as the effect of weight loss on metabolic health.
Over the last 30 years, my research has focused on the role of energy and substrate metabolism in the development of metabolic diseases, such as obesity, diabetes and cardiovascular disease, and particularly have been interested in understanding how lifestyle, including nutrition and physical activity can help to prevent or treat those diseases. In particular, I have been interested in understanding the (molecular) mechanisms underlying the effects of nutrition, exercise and cold exposure on muscle and liver metabolism, with a special interest in mitochondrial function. As a basic scientist by training, my research has initially included both pre-clinical and human interventions, but since the last ~20 years I have focused my research on human translational intervention studies. Given my strong interest in understanding underlying mechanisms, I have initiated and chaired several large international consortia where pre-clinical and clinical studies were combined to cover the full translational spectrum. Currently, my research activities focus on topics such as mitochondrial function in muscle, adipose tissue and liver, the effects of prolonged fasting on (human) metabolism, exercise and nutritional effects on inflammation and energy metabolism as well as the effect of weight loss on metabolic health. I hope to expand this work through collaborative work at the division of Nutritional Sciences of Cornell University.
- De Kam S, van der Velde JHPM, Veelen A, Jörgensen JA, Hoeks J, Schrauwen P. Nocturnal fat oxidation is lower in older individuals with overweight/obesity, including those with type 2 diabetes, and is associated with fasting triglyceride levels. In press, Diabetologia, 2026.
- Harmsen J-F, Habets I, Biancolin A, Lesniewska A, Philips NE, Metz L, Sanchez-Avila J, Kotte M, Timmermans M, Hasim D, de Kam S, Schaart G, Jörgensen JA, Gemmink A, Moonen-Kornips E, Doligkeit D, van de Weijer T, Buitinga M, Haans F, De Lorenzo R, Pallubinsky H, Gordijn MCM, Collet T-H, Kramer A, Schrauwen P*, Dibner C*, Hoeks J*. Natural daylight during office hours improves glucose control and whole-body substrate metabolism. Cell Metabolism, 38 (1), 65-81, 2026.
- Giannakogeorgou A, Kahl S, Granata C, Heilmann G, Mastrototaro L, Dewidar B, Bobrov P, Esposito I, Yavas A, Trenkamp S, Granderath FA, Schlensak M, Mantzoros CS, Roden M, Schrauwen P. Relationship of GDF15 with hepatic mitochondrial respiration is depending on the presence of fibrosis in obese individuals. Metabolism, 173: 156391, 2025.
- Koene EJC, Buziau AM, Cassiman D, Cox TM, Bons J, Scheijen JLJM, Schalkwijk CG, Saxena AR, Esler WP, Schrauwen-Hinderling VB, Schrauwen P*, Brouwers MCGJ*. Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance. Journal of Clinical Investigation, 135 (5), e187376, 2025.
- Parker VE, Robertson D, Tapia EE, Havekes B, Phielix E, de ligt M, Roumans K, Mevenkamp J, Sjoberg F, Schrauwen-Hinderling VB, Johansson E, Chang Y-T, Esterline R, Smith K, Wilkinson DJ, Hansen L, Johansson L, Ambery P, Jermutus L, Schrauwen P. Cotadutide dual GLP-1 and glucagon receptor agonist promotes glycogenolysis and drives beneficial effects on liver health in patients with T2DM and overweight or obesity. Nature Metabolism, 5 (12), 2086-2093, 2023.
- Van Beek SMM, Bruls YMH, vanWeert F, Fealy C, Connell NJ, Schaart G, Kornip E, Jörgensen JA, Vaz FM, Smeets ETHC, Joris PJ, Gemmink A, Houtkooper RH, Hesselink MKC, Bengtson T, Havekes B, Schrauwen P, Hoeks J. Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial. Nature Communication, 14 (1), 173, 2023.
- Connell NJ, Doligkeit D, Andriessen C, Moonen-Kornips E, Bruls YMH, Schrauwen-Hinderling V, van de Weijer T, van Marken-Lichtenbelt WD, Havekes B, Kazak L, Spiegelman BM, Hoeks J, Schrauwen P. No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians. Nature Metabolism, 3 (1), 107-117, 2021.
- Op den Kamp YJM, de Ligt M, Dautzenberg B, Kornips E, Esterline R, Hesselink MKC, Hoeks J, Schrauwen-Hinderling VB, Havekes B, Oscarsson J, Phielix E, Schrauwen P. Effects of the SGLT2 inhibitor dapagliflozin on energy metabolism in patients with type 2 diabetes: a randomized, double-blind crossover trial. Diabetes Care, 44 (6), 1334-1343, 2021.
- Remie CME, Moonen MPB, Roumans KHM, Nascimento EBM, Gemmink A, Havekes B, Schaart G, Kornips E, Joris PJ, Schrauwen-Hinderling VB, Hoeks J, Kersten S, Hesselink MKC, Phielix E, van Marken Lichtenbelt WD, Schrauwen P. Metabolic response to mild cold acclimation in type 2 diabetes patients: a focus on skeletal muscle metabolism. Nature Communication, 12 (1), 1516, 2021.
- Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen P. Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proc Natl Acad Sci U S A, 115, 7789-7794, 2018.
- Hesselink MKC, Schrauwen-Hinderling VB, Schrauwen P. Mitochondria as a target to prevent or treat type 2 diabetes. Nature Reviews Endocrinology, 12 (11), 633-645, 2016.
- Timmers S, de Ligt M, Phielix E, van de Weijer T, Hansen J, Moonen-Kornips E, Schaart G, Kunz I, Hesselink MKC, Schrauwen-Hinderling VB, Schrauwen P. Resveratrol as an add-on therapy in subjects with well-controlled type 2 diabetes: a randomized controlled trial. Diabetes Care, 39 (12), 2211-2217, 2016:
- Broeders EPM, Nascimento EBM, Havekes B, Brans B, Roumans KHM, Tailleux A, Schaart G, Kouach M, Charton J, Deprez B, Bouvy ND, Mottagy F, Staels B, van Marken Lichtenbelt WD, Schrauwen P. The bile acid chenodeoxycholic acid increases human brown adipose tissue activity. Cell Metabolism, 22, 418-426, 2015.
- Hanssen MJW, Hoeks J, Brans B, van der Lans AAJJ, Schaart G, van den Driessche JJ, Jörgensen JA, van Boekschoten MV, Hesselink MKC, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, Schrauwen P. Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nature Medicine, 21, 863-865, 2015.
- Van de Weijer T, Havekes B, Bilet L, Hoeks J, Sparks L, Bosma M, Paglialunga S, Jorgensen J, Janssen MCH, Schaart G, Sauerwein H, Smeets JL, Wildberger J, Zechner R, Schrauwen-Hinderling VB, Hesselink MKC, Schrauwen P. Effects of bezafibrate treatment in a patient and a carrier with mutations in the PNPLA2 gene, causing Neutral Lipid Storage Disease with Myopathy (NLSDM). Circulation Research, 112 (5), e51-54, 2013.
- Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang A-H, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell, 150, 366-376, 2012.
- Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MKC, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen P. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metabolism, 14, 612-622, 2011.
- Marken Lichtenbelt WD van, Vanhommerig JW, Smulder NM, Drossaerts JMAFL, Kemerink GJJ, Schrauwen P, Teule GJJ. Cold-activated brown adipose tissue in healthy adults. New England J Medicine, 360, 1500-1508, 2009.
- Project leader of the international ‘TIMED’ consortium at the Leiden University Medical Center (LUMC), Leiden, The Netherlands
- Associate editor Diabetologia
- Expert panel member European Research Council, section Advanced ERC grants
- Member of the EASD rising star award committee / Minkowski Prize Committee
Deputy head, Research Group Energy Metabolism, Institute for Clinical Diabetology, German Diabetes Center, Düsseldorf, Germany
Office
German Diabetes Center, Auf'm Hennekamp 65, Düsseldorf, Germany
Phone
+31622287422
Email
ps2328@cornell.edu