Chloe is a third-year PhD student in Dr. Martha Field's lab studying folate-mediated one-carbon metabolism (FOCM) and chronic disease. More specifically, she is investigating the roles of folate and vitamin B12 in mitochondrial DNA maintenance and stability, as well as the metabolic consequences of perturbed FOCM. Through her research, she aims to understand how these gene-nutrient interactions shape cellular metabolism and produce biomarkers that reflect health and disease states. In the future, she hopes to leverage her scientific expertise to support innovation in biotech, venture capital, and early-stage R&D strategy, with the long-term goal of advancing impactful therapies and technologies that improve health outcomes and reduce the burden of chronic disease.
 

  • Mellor, C., James, B. T., Azad, S., Kosmeder, E. P., Purello, C. T., Singh, M., Simon, V., Cheng, N. W., Niedermaier, J., Burgos-Barragan, G., Blenis, J. O., Mato, A. R., Field, M. S., & Wang, M. (2026). Excess folate elevates formaldehyde genotoxicity in cell lines but not in mice or humans. EMBO Molecular Medicine, 18(9), 3430–3447. PubMed Central. https://doi.org/10.1038/s44321-026-00504-7
  • Williamson, A. R., Yadav, A., Ma, W., Schmitt, S., Rorrer, S., Odom, L. E., Castillo, L. F., Purello, C. T., Malysheva, O. V., Mobley, J., Field, M., & Thalacker-Mercer, A. E. (2026). Vitamin B12 improves skeletal muscle mitochondrial biology in aged mice. GeroScience. https://doi.org/10.1007/s11357-026-02264-1
  • Kanai, R., McMullan, S., Baniya, P., Dai, R. S., Norton, E., Lasher, K., Purello, C. T., Seavey, C. N., Rubin, B. P., & Lamar, J. M. (2025). AMPK signaling regulates epithelioid hemangioendothelioma cell growth. Cancers, 17(17), 2889. PubMed Central. https://doi.org/10.3390/cancers17172889
  • Lee, J., Purello, C., Booth, S. L., Bennett, B., Wiley, C. D., & Korstanje, R. (2023). Chow Diet in mouse aging studies: Nothing regular about it. GeroScience, 45(3), 2079–2084. https://doi.org/10.1007/s11357-023-00775-9
2022, B.S., Nutritional Sciences, Cornell University